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Sunday, May 17, 2020 | History

2 edition of Dopaminergic 2-aminotetralins and related compounds found in the catalog.

Dopaminergic 2-aminotetralins and related compounds

Anders KarlГ©n

Dopaminergic 2-aminotetralins and related compounds

a molecular mechanics based study

by Anders KarlГ©n

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Published by Uppsala University in Uppsala .
Written in English

    Subjects:
  • Dopamine -- Physiological effect,
  • Molecular pharmacology -- Data processing,
  • Molecular pharmacology

  • Edition Notes

    Statementby Anders Karlén.
    Classifications
    LC ClassificationsRM301.65 .K37 1989
    The Physical Object
    Pagination137 p. :
    Number of Pages137
    ID Numbers
    Open LibraryOL17315654M


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Dopaminergic 2-aminotetralins and related compounds by Anders KarlГ©n Download PDF EPUB FB2

The compounds are related to the dopaminergically active 2-aminotetralins, as well as to apomorphine, and they present the dopamine moiety pharmacophore in the so-called a~conformation.

Nitrogen substituents are those which have been demonstrated previously to confer interesting/ significant biological by: 3. A conformational analysis has been made of the structures of trans- and cis- octahydrobenzo[f]quinoline systems, and this stereochemistry has been related to that of proposed biologically significant conformers of dopamine and of 2-aminodihydroxytetralins.A trans-N-n-propyl octahydrobenzo[f]quinoline exhibited unusually high dopaminergic activity.

The potentiating effect of the N-n-propyl Cited by: 4. The indirect model describes a proposed active agonist conformation for dopaminergic 2-aminotetralins and related compounds and consists of a receptor excluded volume that was used to.

Abstract. The rapid progress in the area of molecular biology has provided us with the primary structures of a large variety of receptor proteins, many of which belong to the G-protein coupled receptor super family (e.g., dopamine (DA) D 1 and D 2 receptors, serotonin (5-HT) 5-HT 1A, 5-HT 1C and 5-HT 2 receptors, and muscarinic m 1 –m 5 receptors).

1–4 These receptor proteins are believed Cited by: 1. In addition, Dopaminergic 2-aminotetralins and related compounds book vivo biological assays on C57BL mice showed that the catechol compou and chie were able to reduce the locomotor activity to act as dopaminergic antagonists [].

Enone prodrugs of dopaminergic catecholamines represent a new type of prodrug in the research area of dopamine agonists. Here, we demonstrate the first benzo[g]quinoline-derived enone that induces potent dopamine agonist effects similar to aminotetralin-derived enones.

Significant effects of (−)-4 were observed in microdialysis studies after administration of 1 nmol kg-1 sc and 3 nmol kg-1 by: Abstract.

Dopamine (DA*), which is chemically defined as β-(3,4-dihydroxyphenyl) ethylamine, 3-hydroxytyramine, or 5-(2-aminoethyl)-1,2-benzenediol, was first synthesized in (Mannich and Jacobsohn, ).Cited by: 3. 5-HT1A receptor is one of the most important members of the numerous families of serotoninergic receptors.

Though it was the first 5-HT receptor to be identified and cloned, the knowledge of its activation/transduction mechanisms, mediated effects, and connection with other systems is still uncompleted. For this reason, relevant is the study of the four Ws of the title: first of all “who Author: Wilma Quaglia, Carlo Cifani, Fabio Del Bello, Mario Giannella, Gianfabio Giorgioni, Maria Vittoria M.

Metal Ions in Biological Systems. Volume Interactions of metal ions with nucleotides, nucleic acids, and their constituents A. Sigel and H. Sigel, Eds.

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Acknowledgments The editors wish to express their gratitude to Cordelia Erickson-Davis, Brendan Fleig-Goldstein, Ella Letort, Olivia Marcus, and Sarvin Tafazoli for. This banner text can have markup. web; books; video; audio; software; images; Toggle navigation.

Zhuming S and Kondabo lu K (equal), Cordova Sintjago T Canal C, Travers S, Kim MS, Fels ing D, Booth RG. Novel 4 Aryl 6,7 Substituted N,N dimethyl 2 aminotetralins: Synthesis and Binding at Serotonin 5 HT2 type and Histamine H1 G Protein Coupled Receptors with In Silico Docking Studies Journal of Medicinal Chemistry,in preparation.

A methylphenidate, particularly including dextro-threo-methylphenidate, is administered to a subject to treat a speech, gait or limb impairment secondary to a genetically acquired pre-frontal cortex processing disease or disorder, particularly including multiple sclerosis, cerebral palsy, Angelman syndrome, Rett syndrome and Fragile-X by: 1.

Ryan Bastle, Individual Pre-Doctoral NRSA Grant (F31), National Institute on Drug Abuse, MicroRNA regulation of addiction-related genes and drug abuse-related behavior, Natalie (Cole) Peartreee, Individual Pre-Doctoral NRSA Grant (F31), National Institute on Drug Abuse, “Social buffering and vulnerability to drug reward,” The Dopamine Receptors T HE R ECEPTORS KIM A.

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Library of Congress Cataloging-in-Publication Data Handbook of biotransformations of aromatic compounds / Brian L. Goodwin. Includes bibliographical. Structural and steric aspects of acetylenic compounds related to oxotremorine (Diss., sammanfattning 50 sid., tab.), av: Resul, Bahram.

Abstracts of Uppsala dissertations from the Faculty of Pharmacy no 70, Almqvist & Wiksell International, Stockholm, ISBN   A Mechanism-based 3D-QSAR Approach for Classification and Prediction of Acetylcholinesterase Inhibitory Potency of Organophosphate and Carbamate Analogs. EPA Science Inventory.

Organophosphate (OP) and carbamate esters can inhibit acetylcholinesterase (AChE) by binding covalently to a serine residue in the enzyme active site, and their inhibitory potency depends. Aci A!

d NADH NAD* 1 2 In order to understand the mechanism of the enzymatic process, the nonenzymatic reduction of substrates by NADH and NADH model compounds (denoted as PyH2, Figure 1) have been extensively studied.

2 But there is still no concensus on whether the process occurs by a one-step hydride transfer or by a multistep mechanism.In particular, attempts to prepare mixed dopamine D2 receptor antagonists and serotonin 5-HT1, agonists sprung from hybrids of substituted benzamides (D2 antagonists) and 2-aminotetralins (5-HT1, agonists).

Enantiomers (R)-1 and (S)-l, among others, were shown to exhibit the relevant biology. -7 N J J qR A (J2%-f3 / 2-aminotetralins. benzamides.《(-)(n-正丙基氨基)羟基四氢化萘的合成》.pdf,第34卷第6期 北京化工大学学报 vd.34.no6 年 journalofbeijinguniversity(孵chemj【1altechn()l』)gy (一).2.(n.正丙基氨基).5.羟基四氢化萘的合成 左洪剑1杜洪光¨ 李 明1 刘喜全2杜振涛2王树明2 (1.北京化工大学理学院,北京1呻;2北京康倍 .